Kashin-Beck disease and iodine deficiency in Tibet
نویسندگان
چکیده
منابع مشابه
Kashin-Beck disease--expanding the spectrum of iodine-deficiency disorders.
Selenium, as selenocysteine, is an integral component of two important enzymes — glutathione peroxidase and iodothyronine deiodinase — that are present in many tissues, including the thyroid gland. Glutathione peroxidase catalyzes the breakdown of hydrogen peroxide, thereby protecting against oxidative damage. Iodothyronine deiodinase catalyzes the deiodination of thyroxine to triiodothyronine,...
متن کاملRare osteoarthritis: ochronosis and Kashin-Beck disease
normally retained in the body because of its high renal clearance; the absence of the HGD enzyme leads to abundant urinary excretion of homogentisic acid, which darkens slowly upon oxidation by prolonged exposure to air. The darkening is hastened by the addition of alkali to the urine and is reflected in the original term for homogentisic acid, alkapton, which refers to its avidity for alkali. ...
متن کاملKashin-Beck disease involving the ankles
We present a case of Kashin-Beck Disease primarily affecting the ankles. Our findings are consistent with other reports of the symptoms, incidence, and progression of these diseases. At this time, our patient has chosen conservative treatment, but is considering eventual osteoarticular allografts. According to the available literature, surgical treatment is the only option that will not only al...
متن کاملMass spectrometry-based proteomic analysis of Kashin-Beck disease.
Kashin-Beck disease (KBD) is a degenerative osteoarticular disease of unknown etiology. The management of KBD would benefit from the identification of the biomarkers related to this disease. In this study, mass spectrometry (MS)-based proteomic profiling was used to identify potential biomarkers of the disease. One hundred and sixteen serum samples of KBD cases and healthy controls were collect...
متن کاملAssociation Study of Polymorphisms in Selenoprotein Genes and Kashin–Beck Disease and Serum Selenium/Iodine Concentration in a Tibetan Population
BACKGROUND Kashin-Beck disease is a kind of degenerative osteoarthropathy. Genetic factors may play an important role in the pathogenesis of KBD. OBJECTIVE To investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699), TrxR2 (rs5748469), and DIO2 (rs225014) with Kashin-Beck disease (KBD) in a Tibetan population and to investigate the association of these...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Orthopaedics
سال: 2001
ISSN: 0341-2695,1432-5195
DOI: 10.1007/s002640000216